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Dose-escalated radiation therapy is associated with better overall survival in patients with bone metastases from solid tumors: a propensity score-matched study.
- Source :
- Cancer Medicine; Sep2017, Vol. 6 Issue 9, p2087-2097, 11p
- Publication Year :
- 2017
-
Abstract
- We aimed to compare the overall survival ( OS) of patients with bone metastases ( BM) from solid tumors after standard-dose radiotherapy ([ RT]; 30 Gy administered in 10 fractions; EQD<subscript>2Gy</subscript> = 32.5 Gy) and dose-escalated RT (EQD<subscript>2Gy</subscript> > 32.5 Gy). We retrospectively reviewed the clinical charts of 1795 patients (median age, 62.3 years; age range, 18-96 years) with BM from solid tumors who were referred for RT to our institute between 2000 and 2013. These patients were assigned to the standard-dose ( n = 1125; 63%) and dose-escalated ( n = 670; 37%) RT groups. OS, estimated as the duration between the first RT session and death, served as the main outcome measure. The dose-escalated RT group had a significantly better OS than the standard-dose RT group ( P = 0.000). After allowing potential confounders in multivariate analysis, the RT dose retained its independent association with OS (hazard ratio [ HR], 0.837; 95% confidence interval [ CI], 0.753-0.929, P = 0.001). After propensity score matching of the baseline characteristics of both groups, RT dose retained its independent association with OS ( HR, 0.887; 95% CI, 0.737-0.951; P = 0.011) on multivariate analysis. Dose-escalated RT exerted more favorable effects on OS in patients with non-lung cancer, those without multiple metastases, those without symptoms, and those with favorable prognosis. Dose-escalated RT was significantly associated with better OS in patients with BM from solid malignancies, particularly among those with non-lung cancer, those without multiple metastases, those without symptoms, and those with favorable prognosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20457634
- Volume :
- 6
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Cancer Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 125219065
- Full Text :
- https://doi.org/10.1002/cam4.1150