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A comparison of blood stream infections with extended spectrum beta-lactamase-producing and non-producing Klebsiella pneumoniae in pediatric patients.
- Source :
- Italian Journal of Pediatrics; 9/12/2017, Vol. 43, p1-7, 7p
- Publication Year :
- 2017
-
Abstract
- Background: Rapid development and global spread of multidrug resistant Klebsiella pneumonia (K. pneumoniae)as a major cause of nosocomial infections is really remarkable. The aim of this study was to explore risk factors for health care associated blood stream infections (BSI) caused by ESBL-producing K. pneumoniae in children and analyze clinical outcomes. Methods: A retrospective review of patients younger than 18 years-old with blood stream infection caused by K. pneumoniae was performed. Patients with ESBL-producing K. pneumoniae isolates were compared with ESBL-non-producing isolates in terms of risk factors, outcome and mortality. Results: Among 111 K. pneumoniae isolates 62% (n = 69) were ESBL -producing K. pneumoniae. The median total length of hospitalization and median length of stay in hospital before infection was significantly higher in patients with ESBL-producing isolates than ESBL-non-producing. Use of combined antimicrobial treatment was significantly different between ESBL-producing and ESBL-non-producing groups, 75.4% and 24.6%, respectively (p = 0.001). Previous aminoglycoside use was higher in cases with ESBL -producing isolates (p = 0.001). Logistic regression analysis showed a significant correlation between mortality and use of combined antibiotics (OR 4.22; p =0.01). Conclusion: ESBL production in K. pneumoniae isolates has a significant impact on clinical course of BSIs. Total length of hospitalization, length of hospital stay before infection, prior combined antibiotic use and use of aminoglycosides were significant risk factors for development of ESBL-producing K. pneumoniae related BSI. [ABSTRACT FROM AUTHOR]
- Subjects :
- AMINOGLYCOSIDES
CROSS infection
BETA lactam antibiotics
ANTIBIOTICS
BACTEREMIA
COMPARATIVE studies
STATISTICAL correlation
DRUG resistance in microorganisms
LENGTH of stay in hospitals
LOGISTIC regression analysis
TREATMENT effectiveness
RETROSPECTIVE studies
DESCRIPTIVE statistics
KLEBSIELLA infections
ODDS ratio
CHILDREN
DISEASE risk factors
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 17208424
- Volume :
- 43
- Database :
- Complementary Index
- Journal :
- Italian Journal of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 125127915
- Full Text :
- https://doi.org/10.1186/s13052-017-0398-0