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Validation of the revised International Prognostic Scoring System in patients with myelodysplastic syndrome in Japan: results from a prospective multicenter registry.

Authors :
Kawabata, Hiroshi
Tohyama, Kaoru
Matsuda, Akira
Araseki, Kayano
Hata, Tomoko
Suzuki, Takahiro
Kayano, Hidekazu
Shimbo, Kei
Zaike, Yuji
Usuki, Kensuke
Chiba, Shigeru
Ishikawa, Takayuki
Arima, Nobuyoshi
Nogawa, Masaharu
Ohta, Akiko
Miyazaki, Yasushi
Mitani, Kinuko
Ozawa, Keiya
Arai, Shunya
Kurokawa, Mineo
Source :
International Journal of Hematology; Sep2017, Vol. 106 Issue 3, p375-384, 10p
Publication Year :
2017

Abstract

The Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes has been conducting prospective registration, central review, and follow-up study for patients with aplastic anemia and myelodysplastic syndrome (MDS) since 2006. Using this database, we retrospectively analyzed the prognosis of patients with MDS. As of May 2016, 351 cases were registered in this database, 186 of which were eligible for the present study. Kaplan-Meier analysis showed that overall survival (OS) curves of the five risk categories stipulated by the revised international prognostic scoring system (IPSS-R) were reasonably separated. 2-year OS rates for the very low-, low-, intermediate-, high-, and very high-risk categories were 95, 89, 79, 35, and 12%, respectively. In the same categories, incidence of leukemic transformation at 2 years was 0, 10, 8, 56, and 40%, respectively. Multivariate analysis revealed that male sex, low platelet counts, increased blast percentage (>2%), and high-risk karyotype abnormalities were independent risk factors for poor OS. Based on these data, we classified Japanese MDS patients who were classified as intermediate-risk in IPSS-R, into the lower risk MDS category, highlighting the need for careful assessment of treatments within low- and high-risk treatment protocols. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09255710
Volume :
106
Issue :
3
Database :
Complementary Index
Journal :
International Journal of Hematology
Publication Type :
Academic Journal
Accession number :
124968511
Full Text :
https://doi.org/10.1007/s12185-017-2250-0