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Circulating resistin levels and risk of multiple myeloma in three prospective cohorts.
- Source :
- British Journal of Cancer; 8/22/2017, Vol. 117 Issue 5, pN.PAG-N.PAG, 1p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Resistin is a polypeptide hormone secreted by adipose tissue. A prior hospital-based case-control study reported serum resistin levels to be inversely associated with risk of multiple myeloma (MM). To date, this association has not been investigated prospectively.<bold>Methods: </bold>We measured resistin concentrations for pre-diagnosis peripheral blood samples from 178 MM cases and 358 individually matched controls from three cohorts participating in the MM cohort consortium.<bold>Results: </bold>In overall analyses, higher resistin levels were weakly associated with reduced MM risk. For men, we observed a statistically significant inverse association between resistin levels and MM (odds ratio, 0.44; 95% confidence interval (CI) 0.24-0.83 and 0.54; 95% CI 0.29-0.99, for the third and fourth quartiles, respectively, vs the lowest quartile; Ptrend=0.03). No association was observed for women.<bold>Conclusions: </bold>This study provides the first prospective evidence that low circulating resistin levels may be associated with an increased risk of MM, particularly for men. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00070920
- Volume :
- 117
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- British Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 124927270
- Full Text :
- https://doi.org/10.1038/bjc.2017.282