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Off-Label Prescribing of Second-Generation Antipsychotics to Elderly Veterans with Posttraumatic Stress Disorder and Dementia.
- Source :
- Journal of the American Geriatrics Society; Aug2017, Vol. 65 Issue 8, p1789-1795, 7p, 3 Charts, 2 Graphs
- Publication Year :
- 2017
-
Abstract
- Objectives To determine whether elderly veterans with posttraumatic stress disorder ( PTSD) and dementia are more likely to be prescribed second-generation antipsychotics ( SGAs) than those with PTSD alone. Design National serial cross-sectional study. Setting Veterans Health Affairs inpatient and outpatient settings. Participants Veterans aged 65 and older with PTSD (excluding schizophrenia or bipolar disorder) with or without concomitant dementia who received care from the Veterans Health Administration between 2003 and 2010 were identified using International Classification of Diseases, Ninth Revision, codes (N = 93,068; 11.1% with dementia). Measurements Trends in SGA prescribing and odds of being prescribed an SGA were determined using a multivariable logistic regression model adjusted for clinical, sociodemographic, and geographic covariates. Results Between 2004 and 2009, SGA prescribing declined annually from 7.0% to 5.1% of elderly veterans with PTSD without dementia and 13.2% to 8.9% in those with dementia; findings over time consistently indicated that veterans with PTSD and dementia had at least twice the odds of being prescribed an SGA as those without PTSD (odds ratios 2.03 (95% confidence interval ( CI) = 1.82-2.26) to 2.33 (95% CI = 2.10-2.58). Conclusion Although the prescribing of SGAs to elderly veterans with PTSD has decreased, prescribing an SGA to those with dementia remained consistently higher than for those with PTSD alone and is problematic given the high prevalence of medical comorbidities in this aging population coupled with the lack of compelling evidence for effectiveness of SGAs in individuals with dementia. [ABSTRACT FROM AUTHOR]
- Subjects :
- OFF-label use (Drugs)
MEDICAL care of older veterans
ANTIPSYCHOTIC agents
POST-traumatic stress disorder in old age
DEMENTIA patients
DRUG prescribing
OUTPATIENT medical care
MEDICAL care
CONFIDENCE intervals
DEMENTIA
VETERANS
MEDICAL prescriptions
POST-traumatic stress disorder
PROBABILITY theory
RESEARCH funding
LOGISTIC regression analysis
EFFECT sizes (Statistics)
CROSS-sectional method
DESCRIPTIVE statistics
ODDS ratio
DRUG administration
DRUG dosage
OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 00028614
- Volume :
- 65
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of the American Geriatrics Society
- Publication Type :
- Academic Journal
- Accession number :
- 124623512
- Full Text :
- https://doi.org/10.1111/jgs.14897