Back to Search
Start Over
Association between maternal vitamin D status in pregnancy and neurodevelopmental outcomes in childhood: results from the Avon Longitudinal Study of Parents and Children (ALSPAC).
- Source :
- British Journal of Nutrition; 6/28/2017, Vol. 117 Issue 12, p1682-1692, 11p
- Publication Year :
- 2017
-
Abstract
- Seafood intake in pregnancy has been positively associated with childhood cognitive outcomes which could potentially relate to the high vitamin D content of oily fish. However, whether higher maternal vitamin D status (serum 25-hydroxyvitamin D (25(OH)D)) in pregnancy is associated with a reduced risk of offspring suboptimal neurodevelopmental outcomes is unclear. A total of 7065 mother–child pairs were studied from the Avon Longitudinal Study of Parents and Children cohort who had data for both serum total 25(OH)D concentration in pregnancy and at least one measure of offspring neurodevelopment (pre-school development at 6–42 months; ‘Strengths and Difficulties Questionnaire’ scores at 7 years; intelligence quotient (IQ) at 8 years; reading ability at 9 years). After adjustment for confounders, children of vitamin D-deficient mothers (<50·0 nmol/l) were more likely to have scores in the lowest quartile for gross-motor development at 30 months (OR 1·20; 95 % CI 1·03, 1·40), fine-motor development at 30 months (OR 1·23; 95 % CI 1·05, 1·44) and social development at 42 months (OR 1·20; 95 % CI 1·01, 1·41) than vitamin D-sufficient mothers (≥50·0 nmol/l). No associations were found with neurodevelopmental outcomes, including IQ, measured at older ages. However, our results suggest that deficient maternal vitamin D status in pregnancy may have adverse effects on some measures of motor and social development in children under 4 years. Prevention of vitamin D deficiency may be important for preventing suboptimal development in the first 4 years of life. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHI-squared test
CONFIDENCE intervals
INFANT development
INTELLIGENCE tests
LONGITUDINAL method
NEUROPSYCHOLOGICAL tests
MOTHERS
NEURONS
NUTRITIONAL requirements
PROBABILITY theory
QUESTIONNAIRES
RESEARCH funding
VITAMIN D
VITAMIN D deficiency
LOGISTIC regression analysis
EFFECT sizes (Statistics)
BODY mass index
DESCRIPTIVE statistics
PRENATAL exposure delayed effects
ODDS ratio
CHILDREN
PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 00071145
- Volume :
- 117
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- British Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 124539124
- Full Text :
- https://doi.org/10.1017/S0007114517001398