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A Phase II Study of the c-Met Inhibitor Tivantinib in Combination with FOLFOX for the Treatment of Patients with Previously Untreated Metastatic Adenocarcinoma of the Distal Esophagus, Gastroesophageal Junction, or Stomach.
- Source :
- Cancer Investigation; 2017, Vol. 35 Issue 7, p463-472, 10p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>This phase I/II study was designed to determine the maximum tolerated dose of tivantinib in combination with standard dose FOLFOX for the treatment of patients with advanced solid tumors and to evaluate the safety and efficacy of this combination for patients with previously untreated metastatic adenocarcinoma of the distal esophagus, gastroesophageal (GE) junction, or stomach.<bold>Methods: </bold>Patients with advanced solid tumors for which FOLFOX would be appropriate chemotherapy received escalating doses of tivantinib BID (days 1-14) in a standard 3 + 3 design in phase I. In phase II, patients with advanced GE cancer received standard FOLFOX day 1 and tivantinib (360 mg PO BID) days 1-14 of each 2-week cycle. Restaging occurred every four cycles. The primary phase II endpoint was response rate (RR).<bold>Results: </bold>Forty-nine patients were enrolled (15 on phase I and 34 on phase II). The expansion dose was established as tivantinib 360 mg BID in combination with FOLFOX. Thirty-two phase II patients were treated for a median of eight cycles (range, 1-38), with an overall RR of 38%. Treatment-related toxicities included neutropenia, fatigue, diarrhea, nausea, and peripheral neuropathy. Median progression-free survival (PFS) was 6.1 hmonths with a median time to progression of 7.0 months. Median overall survival was 9.6 months. Two patients remain on study at the time of this analysis.<bold>Conclusions: </bold>The combination treatment of tivantinib plus FOLFOX in patients with advanced GE cancer showed a response and PFS in the range of historical controls for first-line FOLFOX therapy. However, two patients had extended time on study treatment (36 and 45 cycles) at the time of data cutoff. [ABSTRACT FROM AUTHOR]
- Subjects :
- ADENOCARCINOMA
CANCER treatment
ANTINEOPLASTIC agents
ESOPHAGEAL cancer
ESOPHAGOGASTRIC junction cancer
CLINICAL drug trials
CELLULAR signal transduction
CLINICAL trials
COMPARATIVE studies
DRUG administration
DRUG dosage
DOSE-effect relationship in pharmacology
DRUG toxicity
ESOPHAGUS
ESOPHAGEAL tumors
FLUOROURACIL
FOLINIC acid
HETEROCYCLIC compounds
RESEARCH methodology
MEDICAL cooperation
ORGANOPLATINUM compounds
PROGNOSIS
QUINOLINE
RESEARCH
STOMACH tumors
TIME
EVALUATION research
TREATMENT effectiveness
PROTEIN kinase inhibitors
KAPLAN-Meier estimator
Subjects
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 35
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 124538564
- Full Text :
- https://doi.org/10.1080/07357907.2017.1337782