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Microwave ablation for the treatment of hepatocellular carcinoma that met up-to-seven criteria: feasibility, local efficacy and long-term outcomes.
- Source :
- European Radiology; Sep2017, Vol. 27 Issue 9, p3877-3887, 11p
- Publication Year :
- 2017
-
Abstract
- <bold>Objectives: </bold>This study aimed to evaluate the feasibility, local efficacy and long-term outcomes of microwave (MW) ablation for the treatment of hepatocellular carcinoma (HCC) that met up-to-seven criteria.<bold>Methods: </bold>Between January 2007 and January 2012, 142 HCC patients with 294 nodules, which conformed to up-to-seven criteria, were enrolled into this retrospective study. All patients were followed up for more than 3 years after receiving MW ablation. Technical success, complications, local tumour progression (LTP) and distant recurrence (DR) were monitored. Recurrence-free survival (RFS), overall survival (OS) and prognostic factors were analysed.<bold>Results: </bold>Primary technical efficacy was achieved in 95.2% (280/294) of the carcinomatous nodules, and major complications occurred in four (2.8%) patients. Among the 294 tumours, LTP was observed in 44 (15.0%) tumours. Among the 142 patients, DR was observed in 97 (68.3%) patients. The estimated OS rates after MW ablation at 1, 3 and 5 years were 97.2%, 75.4% and 50.6%, respectively; and the corresponding RFS rates were 76.1%, 33.1% and 19.5%, respectively.<bold>Conclusions: </bold>MW ablation is a safe and effective treatment with a high rate of primary technical efficacy for patients with HCC that met up-to-seven criteria.<bold>Key Points: </bold>• The first study expanding MW ablation to HCC category beyond Milan criteria. • The first report that used up-to-seven criteria as indications for MW ablation. • HCC of up-to-seven criteria viewed as a subgroup of BCLC stage B. • MW ablation is safe and effective for treating HCC within up-to-seven criteria. • MW ablation is preferable in treating unresectable HCC within up-to-seven criteria. [ABSTRACT FROM AUTHOR]
- Subjects :
- LIVER cancer
ABLATION techniques
TREATMENT effectiveness
DISEASE progression
SURGICAL complications
MICROWAVES
CANCER relapse
CATHETER ablation
COMPARATIVE studies
HEPATOCELLULAR carcinoma
LIVER tumors
RESEARCH methodology
MEDICAL cooperation
RESEARCH
SURVIVAL
PILOT projects
EVALUATION research
RETROSPECTIVE studies
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 09387994
- Volume :
- 27
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- European Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 124485430
- Full Text :
- https://doi.org/10.1007/s00330-017-4740-0