Inside Back Cover: 2′β-Fluoro-Tricyclo Nucleic Acids (2′F-tc-ANA): Thermal Duplex Stability, Structural Studies, and RNase H Activation (Chem. Eur. J. 43/2017).

What a difference a fluorine makes when introduced into the 2′ ‐ β ‐ position of the tricyclo ‐ DNA skeleton (2′F ‐ tc ‐ ANA). It steers the conformation of the furanose unit into an eastern conformation. Fully modified 2′F ‐ tc ‐ ANA shows enhanced binding to complementary RNA in the same way as parent tc ‐ DNA. Embedded in a 2′OMe ‐ RNA hybrid construct it enables RNaseH cleavage of a complementary RNA target, thus enhancing the application range of the tc ‐ DNA family as antisense agents. More information can be found in the Full Paper by C. J. Leumann et al. on page 10310. [ABSTRACT FROM AUTHOR]