Primary photochemical processes for Pt(iv) diazido complexes prospective in photodynamic therapy of tumors.

Authors :: Shushakov, Anton A.
Pozdnyakov, Ivan P.
Grivin, Vjacheslav P.
Plyusnin, Victor F.
Vasilchenko, Danila B.
Zadesenets, Andrei V.
Melnikov, Alexei A.
Chekalin, Sergey V.
Glebov, Evgeni M.
Source :: Dalton Transactions: An International Journal of Inorganic Chemistry; 8/7/2017, Vol. 46 Issue 29, p9440-9450, 11p
Publication Year :: 2017
Abstract: Diazide diamino complexes of Pt(iv) are considered as prospective prodrugs in oxygen-free photodynamic therapy (PDT). Primary photophysical and photochemical processes for cis,trans,cis-[Pt(N<subscript>3</subscript>)<subscript>2</subscript>(OH)<subscript>2</subscript>(NH<subscript>3</subscript>)<subscript>2</subscript>] and trans,trans,trans-[Pt(N<subscript>3</subscript>)<subscript>2</subscript>(OH)<subscript>2</subscript>(NH<subscript>3</subscript>)<subscript>2</subscript>] complexes were studied by means of stationary photolysis, nanosecond laser flash photolysis and ultrafast kinetic spectroscopy. The process of photolysis is multistage. The first stage is the photosubstitution of an azide ligand to a water molecule. This process was shown to be a chain reaction involving redox stages. Pt(iv) and Pt(iii) intermediates responsible for the chain propagation were recorded using ultrafast kinetic spectroscopy and nanosecond laser flash photolysis. The mechanism of photosubstitution is proposed. [ABSTRACT FROM AUTHOR]

Subjects :: PRIMARY photochemical processes
PHOTODYNAMIC therapy
ELECTRON-transfer catalysis

Language :: English
ISSN :: 14779226
Volume :: 46
Issue :: 29
Database :: Complementary Index
Journal :: Dalton Transactions: An International Journal of Inorganic Chemistry
Publication Type :: Academic Journal
Accession number :: 124300175
Full Text :: https://doi.org/10.1039/c7dt01529a

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