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Associations of Prenatal Urinary Bisphenol A Concentrations with Child Behaviors and Cognitive Abilities.
- Source :
- Environmental Health Perspectives; Jun2017, Vol. 125 Issue 6, p1-9, 9p, 2 Charts, 2 Graphs
- Publication Year :
- 2017
-
Abstract
- BACKGROUND: Prenatal bisphenol A (BPA) exposure has been associated with adverse neurodevelopment in epidemiological studies. However, prior studies had limited statistical power to examine sex-specific effects, and few examined child cognition. OBJECTIVES: We estimated the association between prenatal BPA exposure and child neurobehavior at 3 y of age in a prospective cohort of 812 mothers and their children. METHODS: We measured BPA concentration in urine samples collected at ∼12 wk gestation among women enrolled in a 10-city Canadian cohort study. At approximately 3 y of age, we assessed children's cognitive abilities with the Wechsler Primary and Preschool Scale of Intelligence™-III (WPPSI-III) and two scales of the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P). Parents reported children's behavior using the Behavior Assessment System for Children-2 (BASC-2) and the Social Responsiveness Scale™-2 (SRS-2). We estimated covariate-adjusted differences in neurobehavioral outcomes with a doubling in BPA concentration and sex-specific associations. RESULTS: BPA was not associated with WPPSI-III scores; child sex did not modify these associations. The association between BPA and BRIEF-P scores was modified by child sex (BPA×sex p-values≤0.03). For example, a doubling of BPA concentration was associated with 1-point (95% CI: 0.3, 1.7) poorer working memory in boys and 0.5-point (95% CI: -1.1, 0.1) better scores in girls. BPA was not associated with most BASC-2 scales; however, it was associated with more internalizing and somatizing behaviors in boys, but not in girls (BPA×sexp-values≤0.08). A doubling of BPA concentration was associated with poorer SRS-2 scores [β=0.3 ( 95% CI: 0, 0.7)]; this association was not modified by sex. CONCLUSION: Prenatal urinary BPA concentration was associated with some aspects of child behavior in this cohort, and some associations were stronger among boys. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHILD behavior
COGNITIVE testing
CONFIDENCE intervals
SYNTHETIC gums & resins
LONGITUDINAL method
MEDICAL cooperation
MOTHERS
NERVOUS system
PHENOLS
PROBABILITY theory
RESEARCH
RESEARCH funding
SEX distribution
SHORT-term memory
MULTIPLE regression analysis
DESCRIPTIVE statistics
CHILDREN
PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 00916765
- Volume :
- 125
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Environmental Health Perspectives
- Publication Type :
- Academic Journal
- Accession number :
- 124228390
- Full Text :
- https://doi.org/10.1289/EHP984