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Assessment of subclinical atherosclerosis in hidradenitis suppurativa.
- Source :
- Journal of the European Academy of Dermatology & Venereology; Jul2017, Vol. 31 Issue 7, p1229-1238, 10p
- Publication Year :
- 2017
-
Abstract
- Background Patients with hidradenitis suppurativa ( HS) have an increased prevalence of traditional cardiovascular risk factors. Objective Our aim was to investigate the association between subclinical atherosclerosis, detected by carotid ultrasound, and HS. Methods A prospective observation and analytical study assessing subclinical atherosclerosis using carotid ultrasound in patients with HS. Results A total of 62 HS patients and 62 matched controls were studied. Diabetes mellitus (22.6% vs. 6.5%, P = 0.020), hypertension (41.9% vs. 12.9%, P < 0.001) and metabolic syndrome (MetS) (38.7% vs. 8.1%, P < 0.001) were more common in HS patients. Elevated neutrophil-to-lymphocyte ratio (59.7% vs. 40.3%, P = 0.031), high-sensitivity C-reactive protein (61.1 vs. 29.0%, P < 0.001) and erythrocyte sedimentation rate (46.8% vs. 9.7%, P < 0.001) were more frequent in patients with HS. Subclinical atherosclerosis was present in 30.6% of HS patients and in 16.1% of the controls subjects ( P = 0.06). After a logistic regression analysis, elevated age was associated with the presence of subclinical atherosclerosis ( P < 0.001), and HS showed a tendency towards this association [adjusted OR (95% CI) 3.8 (0.9-16.0), P = 0.066]. This association was statistically significant between patients 40 years and older [ OR (95% CI) 4.9 (1.8-13.1)]. Conclusions Our clinical results indicate that patients with HS have a higher prevalence of subclinical atherosclerosis than expected when correcting for traditional risk factors. The findings support the conclusions of previous epidemiological studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09269959
- Volume :
- 31
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of the European Academy of Dermatology & Venereology
- Publication Type :
- Academic Journal
- Accession number :
- 124220131
- Full Text :
- https://doi.org/10.1111/jdv.14076