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Sulfamic Acid Catalyzed Atom Economic, Eco-friendly Synthesis of Novel 7-(Aryl)-10-thioxo-7,9,10,11-tetrahedro-6 H-pyrimido-[5′4′:5,6]pyrano[3,2-c]quinoline-6,8(5 H)-dione and its Derivatives.
- Source :
- Journal of Heterocyclic Chemistry; Jul2017, Vol. 54 Issue 4, p2206-2215, 10p
- Publication Year :
- 2017
-
Abstract
- A series of novel 7-(3-chloro-phenyl)-10-thioxo-7,9,10,11-tetrahedro-6 H-pyrimido-[5′4′:5,6] pyrano[3,2-c]quinoline-6,8(5 H)-dione derivatives have been synthesized through the multi-component condensation of aromatic aldehydes, barbituric acid, and 2,4-dihydroxy quinoline, using heterogeneous sulfamic acid catalyst in water-ethanol (4:1) solvent system under reflux condition. The present protocol is endowed with charming description such as green synthetic procedure, short reaction time, easy work-up procedure, and excellent yield and high atom economy of pyranoquinoline derivatives. In this study, sulfamic acid is used as a heterogeneous catalyst that is easily recoverable and recyclable. The proposed multi-component reaction has been studied with detail mechanism and spectroscopic data. This is one of the potential greener synthetic approaches to build up the series of pyranoquinoline heterocycles. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0022152X
- Volume :
- 54
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Heterocyclic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 124203354
- Full Text :
- https://doi.org/10.1002/jhet.2807