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Deranged regulatory T-cells and transforming growth factor-β1 levels in type 1 diabetes patients with associated autoimmune diseases.
- Source :
- Journal of Postgraduate Medicine; Jul-Sep2017, Vol. 63 Issue 3, p176-181, 6p
- Publication Year :
- 2017
-
Abstract
- Aim: This study was designed to enumerate regulatory T‑cells (Tregs) and estimate transforming growth factor‑β1 (TGF‑β1) levels in type 1 diabetic (T1D) patients with respect to disease duration and associated autoimmune diseases. Methods: One hundred and fifty patients and twenty healthy controls were recruited in the study. The patients were subcategorized into eight categories on the basis of disease duration (new onset [NO] and long standing [LS]) and associated diseases, i.e., celiac disease (CD) and autoimmune thyroid disease (AiTD). Treg cells were assessed as CD4+ CD25hi+, FOXP3+ cells and serum TGF‑β1 levels were assessed by ELISA. Results: The frequency of Tregs and levels of TGF‑β1 were significantly increased in the patients compared to the healthy controls. Among the different categories of the patients, no significant differences were seen for TGF- β1 levels, but for Tregs in patients with T1D and AiTD (P = 0.035). A significant correlation was also found between percentage count of Tregs and TGF‑β1 levels in NO cases in all disease subcategories, but not in LS patients. Conclusion: Thus, there was an increased percentage of Tregs and serum levels of TGF‑β1 in T1D patients, irrespective of the disease duration and associated autoimmune diseases. The significant correlation in these two parameters at the onset of the disease, but not in LS disease, indicates that the immunological milieu in LS autoimmune diseases is more complicated with disease‑associated conditions such as prolonged hyperglycemia, insulin therapy, and/or continued gluten in diet. Treatment and modulation of these long‑term complications for improving immunological parameters require further research. [ABSTRACT FROM AUTHOR]
- Subjects :
- CELIAC disease diagnosis
T cells
AGE factors in disease
TYPE 1 diabetes
AUTOIMMUNE diseases
CELL physiology
STATISTICAL correlation
PEOPLE with diabetes
GROWTH factors
RESEARCH funding
T-test (Statistics)
THYROID diseases
TRANSFORMING growth factors-beta
CONTROL groups
ACQUISITION of data
PATIENT selection
DISEASE duration
DATA analysis software
CD4 lymphocyte count
MANN Whitney U Test
KRUSKAL-Wallis Test
BLOOD
DIAGNOSIS
GENETICS
PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00223859
- Volume :
- 63
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Postgraduate Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 124182455
- Full Text :
- https://doi.org/10.4103/jpgm.JPGM_608_16