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Evolving Concepts in Atopic Dermatitis.

Authors :
Sidbury, Robert
Khorsand, Kate
Source :
Current Allergy & Asthma Reports; Jul2017, Vol. 17 Issue 7, p1-7, 7p
Publication Year :
2017

Abstract

Purpose of Review: Tremendous advances have been made in the field of atopic dermatitis in the past 5 years. We will explore developments in burden of disease, co-morbidities, pathogenesis, prevention, and management. Recent Findings: The tremendous burden moderate to severe atopic dermatitis (AD) places on families from a medical, psychosocial, and financial perspective has been characterized. Epidemiologic studies have identified intriguing new associations beyond the well-characterized 'atopic march' of food allergies, asthma, and hay fever. Studies of primary prevention have gained traction including the remarkable impacts of early emollient therapy. Basic advances have simultaneously elucidated the nature of atopic inflammation, setting the stage for an explosion of new potential therapeutic targets. After a fallow period of nearly 15 years without a substantial therapeutic advance, this year has already seen two new FDA-approved treatments for AD. Summary: AD has a tremendous impact on quality of life with an underappreciated burden of disease; there are important newly described co-morbidities including ADHD and anemia; new insights into etio-pathogenesis have paved the way for novel topical therapies like crisaborole, and new systemic interventions like dupilumab. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15297322
Volume :
17
Issue :
7
Database :
Complementary Index
Journal :
Current Allergy & Asthma Reports
Publication Type :
Academic Journal
Accession number :
124131537
Full Text :
https://doi.org/10.1007/s11882-017-0710-5