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Neuroprotective effect of α-mangostin on mitochondrial dysfunction and α-synuclein aggregation in rotenone-induced model of Parkinson’s disease in differentiated SH-SY5Y cells.
- Source :
- Journal of Asian Natural Products Research; Aug2017, Vol. 19 Issue 8, p833-845, 13p
- Publication Year :
- 2017
-
Abstract
- The study was designed to evaluate the protective effect of α-mangostin and explore its mechanism in anin vitromodel of Parkinson’s disease (PD) induced by rotenone. SH-SY5Y cells were treated with rotenone and α-mangostin for 24 h. α-Mangostin significantly and concentration-dependently inhibited rotenone-induced cytotoxicity. The rotenone-induced aggregation of α-synuclein and loss of TH were alleviated by α-mangostin. α-Mangostin treatment also reversed the rotenone-induced overproduction of reactive oxygen species, activation of caspases (−8 and −3) and mitochondrial dysfunction, reflected by decrease in mitochondrial membrane potential and cellular ATP levels. These findings suggest that α-mangostin has neuroprotective effects against PD-related neuronal injury. [ABSTRACT FROM PUBLISHER]
- Subjects :
- ANIMAL experimentation
ANISOTROPY
APOPTOSIS
CATTLE
CELL culture
FLOW cytometry
FLUORIMETRY
MITOCHONDRIAL pathology
MOLECULAR structure
NEUROBLASTOMA
PARKINSON'S disease
RESEARCH funding
T-test (Statistics)
WESTERN immunoblotting
ISOFLAVONES
DATA analysis software
DESCRIPTIVE statistics
IN vitro studies
ONE-way analysis of variance
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 19
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 124023791
- Full Text :
- https://doi.org/10.1080/10286020.2017.1339349