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One-pot synthesis of 4-aryl-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin derivatives in glycerol.
- Source :
- Green Chemistry Letters & Reviews; Sep2017, Vol. 10 Issue 3, p134-137, 4p
- Publication Year :
- 2017
-
Abstract
- Glycerol is a new green organic solvent. It not only acts as a phase transfer catalyst but also as a recyclable solvent by significantly enhancing the intramolecular cyclization. A series of 4-aryl-7,7 -dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin derivatives were synthesized by one-pot multicomponent reaction of Meldrum’s acid with benzaldehyde, and cyclohexanedione in glycerol. Compared to classic methods, this method has the advantages of milder reaction conditions, good yields, easy processing and environmental benignity. [ABSTRACT FROM AUTHOR]
- Subjects :
- ETHANES
GLYCERIN
ORGANIC solvents
PHASE-transfer catalysis
BENZALDEHYDE
Subjects
Details
- Language :
- English
- ISSN :
- 17518253
- Volume :
- 10
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Green Chemistry Letters & Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 123762700
- Full Text :
- https://doi.org/10.1080/17518253.2017.1326530