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Live high, train low - influence on resting and post-exercise hepcidin levels.
- Source :
- Scandinavian Journal of Medicine & Science in Sports; Jul2017, Vol. 27 Issue 7, p704-713, 10p
- Publication Year :
- 2017
-
Abstract
- The post-exercise hepcidin response during prolonged (>2 weeks) hypoxic exposure is not well understood. We compared plasma hepcidin levels 3 h after exercise [6 × 1000 m at 90% of maximal aerobic running velocity ( vVO<subscript>2max</subscript>)] performed in normoxia and normobaric hypoxia (3000 m simulate altitude) 1 week before, and during 14 days of normobaric hypoxia [196.2 ± 25.6 h (median: 200.8 h; range: 154.3-234.8 h) at 3000 m simulated altitude] in 10 well-trained distance runners (six males, four females). Venous blood was also analyzed for hepcidin after 2 days of normobaric hypoxia. Hemoglobin mass (Hb<subscript>mass</subscript>) was measured via CO rebreathing 1 week before and after 14 days of hypoxia. Hepcidin was suppressed after 2 (Cohen's d = −2.3, 95% confidence interval: [−2.9, −1.6]) and 14 days of normobaric hypoxia ( d = −1.6 [−2.6, −0.6]). Hepcidin increased from baseline, 3 h post-exercise in normoxia ( d = 0.8 [0.2, 1.3]) and hypoxia ( d = 0.6 [0.3, 1.0]), both before and after exposure (normoxia: d = 0.7 [0.3, 1.2]; hypoxia: d = 1.3 [0.4, 2.3]). In conclusion, 2 weeks of normobaric hypoxia suppressed resting hepcidin levels, but did not alter the post-exercise response in either normoxia or hypoxia, compared with the pre-exposure response. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09057188
- Volume :
- 27
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Medicine & Science in Sports
- Publication Type :
- Academic Journal
- Accession number :
- 123348465
- Full Text :
- https://doi.org/10.1111/sms.12685