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The First Report of Two Cases of Fatal Liver Injury Due to Anti-tuberculosis Drugs in the Presence of Alpha-1 Antitrypsin Deficiency.

Authors :
Habibzadeh, Shahram
Shahi, Jafar Mohammad
Ghobadi, Hassan
Maleki, Nasrollah
Source :
International Journal of Mycobacteriology; Apr-Jun2017, Vol. 6 Issue 2, p187-190, 4p
Publication Year :
2017

Abstract

Tuberculosis (TB) is a major global health problem. Awareness of liver injury due to anti-TB therapy is vital because fulminant hepatic failure is a devastating and often fatal condition without liver transplantation. Here, we report for the first time, two patients of fatal liver injury due to anti-TB drugs in the presence of alpha-1 antitrypsin deficiency. Based on the triad of rapid loss in hepatocyte function, the onset of hepatic encephalopathy, and absence of a prior history of liver disease, the diagnosis of acute liver failure was established. Both patients had low levels of serum alpha-1 antitrypsin, consistent with alpha-1 antitrypsin deficiency. Despite aggressive medical therapy and supportive care, patients developed multi-organ failure and died. It seems measuring the serum levels of alpha 1-antitrypsin before beginning anti-TB therapies is necessary, especially when there is emphysema or bronchiectasis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22125531
Volume :
6
Issue :
2
Database :
Complementary Index
Journal :
International Journal of Mycobacteriology
Publication Type :
Academic Journal
Accession number :
123322428
Full Text :
https://doi.org/10.4103/ijmy.ijmy_60_17