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Enantioselective alkynylation of N-sulfonyl α-ketiminoesters via a Friedel–Crafts alkylation strategy.
- Source :
- Chemical Communications; 5/28/2017, Vol. 53 Issue 43, p5890-5893, 4p
- Publication Year :
- 2017
-
Abstract
- Enantioselective alkynylation of cyclic N-sulfonyl α-ketiminoesters with terminal alkynes was developed by using an Ni(ClO<subscript>4</subscript>)<subscript>2</subscript>/(R)-DTBM-Segphos complex as a catalyst. A range of propargylic amides bearing quaternary stereocenters were afforded in excellent enantioselectivities (up to 97% ee). Theoretical studies revealed that this reaction proceeded via a Friedel–Crafts-type reaction pathway. [ABSTRACT FROM AUTHOR]
- Subjects :
- ENANTIOSELECTIVE catalysis
HETEROGENEOUS catalysis
ESTERS
ALKYNES
HYDROCARBONS
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 53
- Issue :
- 43
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 123319807
- Full Text :
- https://doi.org/10.1039/c7cc01015j