DIFFUSION KURTOSIS IMAGING METRICS AS NON-INVASIVE BIOMARKERS IN BRAIN GLIOMA GRADING.

DKI parameters exhibit higher sensitivity and specificity in discriminating between various glioma’s grades than the DTI parameters, exhibiting higher sensitivity to microstructural changes occurring during malignancy progression. DKI provides valuable non-invasive biomarkers in assessment of gliomas and has been shown to be a useful supplement to other modern neuroimaging methods. This is the first time when kurtosis anisotropy (KA) was applied in glioma grade differentiation. [ABSTRACT FROM AUTHOR]