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The role of tumor microenvironment in collective tumor cell invasion.

The role of tumor microenvironment in collective tumor cell invasion.

Authors :
Wu, Jia-shun
Sheng, Su-rui
Liang, Xin-hua
Tang, Ya-ling
Source :
Future Oncology; May2017, Vol. 13 Issue 11, p991-1002, 12p
Publication Year :
2017

Abstract

For many cancer types, cancer cells invade into surrounding tissues by collective movement of cell groups that remain connected via cell-cell junctions. This migration is completely distinguished from single-cell migration, in which cancer cells disrupt the tight intercellular junctions and gain a mesenchymal phenotype. Recently, emerging evidence has revealed that collective cell invasion depends on not only cell-intrinsic mechanisms but also on extracellular mechanisms by bidirectional interplay between the tumor cell and the tumor environment. Herein, in this review we discuss the role and underline mechanisms of tumor microenvironment in collective tumor cell invasion, particularly focusing on extracellular matrix remodeling and cross-talk between tumor and stromal cells. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14796694
Volume :
13
Issue :
11
Database :
Complementary Index
Journal :
Future Oncology
Publication Type :
Academic Journal
Accession number :
123278917
Full Text :
https://doi.org/10.2217/fon-2016-0501