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Extended RAS analysis and correlation with overall survival in advanced pancreatic cancer.
- Source :
- British Journal of Cancer; 5/23/2017, Vol. 116 Issue 11, p1462-1469, 8p, 4 Charts, 1 Graph
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Mutations in the KRAS gene can be detected in about 70-90% of pancreatic cancer (PC) cases. Whether these mutations have a prognostic or predictive value remains elusive. Furthermore, the clinical relevance of the extended RAS (KRAS+NRAS) mutational status is unclear in PC.<bold>Methods: </bold>We prospectively defined a PC patient population who received erlotinib-free chemotherapy regimens. A statistically significant difference between KRAS wild-type and KRAS mutated tumours in at least 160 patients in this population would support the assumption of a rather prognostic role of KRAS.<bold>Results: </bold>One hundred and seventy-eight tumour samples were collected from prospective clinical studies and successfully analysed for the extended RAS status: 37 tumours were KRAS wild-type (21%), whereas 141 (79%) carried a KRAS mutation; 132 of these mutations were found in KRAS exon 2 (74%), whereas only 9 mutations (5%) were detected in KRAS exon 3. Within KRAS exon 4 and NRAS exons 2-4, no mutations were apparent. There was no significant difference in overall survival for KRAS wild-type vs mutant patients (9.9 vs 8.3 months, P=0.70).<bold>Conclusions: </bold>Together with the results of the AIO-PK-0104-trial, the present analysis supports the notion that KRAS mutation status is rather predictive than prognostic in advanced PC. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTINEOPLASTIC agents
ADENOCARCINOMA
CISPLATIN
CLINICAL trials
COMPARATIVE studies
EPIDERMAL growth factor
GENES
HYDROLASES
RESEARCH methodology
MEDICAL cooperation
MEMBRANE proteins
ORGANOPLATINUM compounds
PANCREATIC tumors
PROGNOSIS
PROTEINS
RESEARCH
SURVIVAL
TUMOR antigens
EVALUATION research
DEOXYCYTIDINE
SEQUENCE analysis
CHEMICAL inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 00070920
- Volume :
- 116
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- British Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 123209186
- Full Text :
- https://doi.org/10.1038/bjc.2017.115