ILDR1 is important for paracellular water transport and urine concentration mechanism.

Authors :: Yongfeng Gong
Himmerkus, Nina
Sunq, Abby
Milatz, Susanne
Merkel, Cosima
Bleich, Markus
Jianghui Hou
Source :: Proceedings of the National Academy of Sciences of the United States of America; 5/16/2017, Vol. 114 Issue 20, p5271-5276, 6p
Publication Year :: 2017
Abstract: The article discusses the importance of immunoglobulin (Ig)-like domain containing receptor 1 (ILDR1) gene for urine concentration mechanism and paracellular water transport. Topics include the significance of tricellular tight junction for water permeation, the impact of genetic knockout of Ildr1 in the kidney of mouse, and the therapeutic strategy to maintain water homeostasis.

Subjects :: IMMUNOGLOBULIN receptors
HOMEOSTASIS
GENE expression
WATER in the body
LABORATORY mice

Language :: English
ISSN :: 00278424
Volume :: 114
Issue :: 20
Database :: Complementary Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 123144889
Full Text :: https://doi.org/10.1073/pnas.1701006114

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