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Pathogenesis of meningococcal purpura fulminans.
- Source :
- Pathogens & Disease; Apr2017, Vol. 75 Issue 3, p1-7, 7p, 1 Diagram
- Publication Year :
- 2017
-
Abstract
- Purpura fulminans (PF) is a dreadful and frequent complication of Neisseria meningitidis invasive infection, and is associated with a high mortality rate. This syndrome begins with dermal microvessels thrombosis that rapidly lead to hemorrhagic skin necrosis. In this review, we discuss the prothrombotic events occurring during meningococcal infection. Moreover, recent data from an experimental mouse model have highlighted the critical role of the meningococcus adhesion to the endothelium in the development of PF lesions, thus opening new therapeutic perspectives. [ABSTRACT FROM AUTHOR]
- Subjects :
- PURPURA (Pathology)
NEISSERIA meningitidis
LABORATORY mice
ENDOTHELIUM
THROMBOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 2049632X
- Volume :
- 75
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Pathogens & Disease
- Publication Type :
- Academic Journal
- Accession number :
- 123094706
- Full Text :
- https://doi.org/10.1093/femspd/ftx027