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Analysis of aqueous humor concentrations of cytokines in retinoblastoma.
- Source :
- PLoS ONE; 5/9/2017, Vol. 12 Issue 5, p1-8, 8p
- Publication Year :
- 2017
-
Abstract
- To investigate in patients with retinoblastoma (RB). We collected 0.1 ml AH of 35 children with RB and 20 patients with congenital cataracts as controls. Multiplex enzyme-linked immunosorbent assays (ELISAs) and Luminex xMAP technology were used to assess 45 cytokines/chemokines, matrix metalloproteinases (MMPs), and acute-phase proteins in the identification cohort. The concentrations of IL-6, IL-7, IL-8, IFN-γ, PIGF-1, VEGF-A, β-NGF, HGF, EGF and FGF-2 were significantly higher in the AH of patients with RB than those in the control group (P<0.05). The study showed that the higher levels of IP-10, IL-6, IL-7, IL-8, IFN-γ, PIGF-1, VEGF-A, β-NGF, HGF, EGF and FGF-2 in AH may be associated with RB. Our findings may facilitate a better understanding of the molecular pathways of tumors and solid molecular targets for new strategies for therapy and the earlier diagnosis of RB. [ABSTRACT FROM AUTHOR]
- Subjects :
- RETINOBLASTOMA
CYTOKINES
IMMUNOREGULATION
CATARACT
METALLOPROTEINASES
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 122942275
- Full Text :
- https://doi.org/10.1371/journal.pone.0177337