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Metabolic Mediators of the Association Between Adult Weight Gain and Colorectal Cancer: Data From the European Prospective Investigation Into Cancer and Nutrition (EPIC) Cohort.

Authors :
Aleksandrova, Krasimira
Schlesinger, Sabrina
Fedirko, Veronika
Jenab, Mazda
Bueno-de-Mesquita, Bas
Freisling, Heinz
Romieu, Isabelle
Pischon, Tobias
Kaaks, Rudolf
Gunter, Marc J.
Dahm, Christina C.
Overvad, Kim
Rostgaard-Hansen, Agnetha Linn
Tjønneland, Anne
Trichopoulou, Antonia
Bamia, Christina
Lagiou, Pagona
Agnoli, Claudia
Mattiello, Amalia
Bradbury, Kathryn
Source :
American Journal of Epidemiology; May2017, Vol. 185 Issue 9, p751-764, 14p
Publication Year :
2017

Abstract

Evidence indicates that gaining weight in adult life is associated with an elevated risk of colorectal cancer; however, biological mechanisms that may explain this association remain unclear. We evaluated the mediation effect of 20 different biomarkers on the relationship between adult weight gain and colorectal cancer, using data from a prospective nested case-control study of 452 incident cases diagnosed between 1992 and 2003 and matched within risk sets to 452 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The proportions of mediated effects (%) were estimated on the basis of differences in percent effect changes in conditional logistic regression models with and without additional adjustment for individual biomarkers. Greater adult weight gain (≥300 g/year vs. <300 g/year) was associated with a higher risk of colon cancer (multivariableadjusted relative risk = 1.54, 95% confidence interval: 1.07, 2.24) but not rectal cancer (relative risk = 1.07, 95% confidence interval: 0.68, 1.66). This association was accounted for mostly by attained waist circumference (reduction of 61%) and by the biomarkers soluble leptin receptor (reduction of 43%) and glycated hemoglobin (reduction of 28%). These novel data suggest that the observed association between adult weight gain and colon cancer could be primarily explained by attained abdominal fatness and biomarkers of metabolic dysfunction. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00029262
Volume :
185
Issue :
9
Database :
Complementary Index
Journal :
American Journal of Epidemiology
Publication Type :
Academic Journal
Accession number :
122824339
Full Text :
https://doi.org/10.1093/aje/kww194