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Adult Patients With Bronchiectasis: A First Look at the US Bronchiectasis Research Registry.
- Source :
- CHEST; May2017, Vol. 151 Issue 5, p982-992, 11p
- Publication Year :
- 2017
-
Abstract
- <bold>Objectives: </bold>We sought to describe the characteristics of adult patients with bronchiectasis enrolled in the US Bronchiectasis Research Registry (BRR).<bold>Methods: </bold>The BRR is a database of patients with non-cystic-fibrosis bronchiectasis (NCFB) enrolled at 13 sites in the United States. Baseline demographic, spirometric, imaging, microbiological, and therapeutic data were entered into a central Internet-based database. Patients were subsequently analyzed by the presence of NTM.<bold>Results: </bold>We enrolled 1,826 patients between 2008 and 2014. Patients were predominantly women (79%), white (89%), and never smokers (60%), with a mean age of 64 ± 14 years. Sixty-three percent of the patients had a history of NTM disease or NTM isolated at baseline evaluation for entry into the BRR. Patients with NTM were older, predominantly women, and had bronchiectasis diagnosed at a later age than those without NTM. Gastroesophageal reflux disease (GERD) was more common in those with NTM, whereas asthma, primary immunodeficiency, and primary ciliary dyskinesia were more common in those without NTM. Fifty-one percent of patients had spirometric evidence of airflow obstruction. Patients with NTM were more likely to have diffusely dilated airways and tree-in-bud abnormalities. Pseudomonas and Staphylococcus aureus isolates were cultured less commonly in patients with NTM. Bronchial hygiene measures were used more often in those with NTM, whereas antibiotics used for exacerbations, rotating oral antibiotics, steroid use, and inhaled bronchodilators were more commonly used in those without NTM.<bold>Conclusions: </bold>Adult patients with bronchiectasis enrolled in the US BRR are described, with differences noted in demographic, radiographic, microbiological, and treatment variables based on stratification of the presence of NTM. [ABSTRACT FROM AUTHOR]
- Subjects :
- BRONCHIECTASIS
CYSTIC fibrosis
CIGARETTE smokers
GASTROESOPHAGEAL reflux
DYSKINESIAS
PATIENTS
STATISTICS on Black people
STATISTICS on Hispanic Americans
ANIMALS
ASTHMA
COMPUTED tomography
ETHNIC groups
IMMUNOLOGICAL deficiency syndromes
HEALTH insurance
MEDICAL research
MYCOBACTERIAL diseases
MYCOBACTERIUM
PSEUDOMONAS
PSEUDOMONAS diseases
RESPIRATORY measurements
RHINITIS
SINUSITIS
SMOKING
SPIROMETRY
STAPHYLOCOCCAL diseases
STAPHYLOCOCCUS aureus
WHITE people
COMORBIDITY
OTITIS
ACQUISITION of data
RESPIRATORY organ abnormalities
VITAL capacity (Respiration)
Subjects
Details
- Language :
- English
- ISSN :
- 00123692
- Volume :
- 151
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- CHEST
- Publication Type :
- Academic Journal
- Accession number :
- 122719743
- Full Text :
- https://doi.org/10.1016/j.chest.2016.10.055