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The cohort multiple randomized controlled trial design: a valid and efficient alternative to pragmatic trials?
- Source :
- International Journal of Epidemiology; Feb2017, Vol. 46 Issue 1, p96-102, 7p
- Publication Year :
- 2017
-
Abstract
- Randomized controlled trials (RCTs)-the gold standard for evaluating the effects of medical interventions-are notoriously challenging in terms of logistics, planning and costs. The cohort multiple randomized controlled trial approach is designed to facilitate randomized trials for pragmatic evaluation of (new) interventions and is a promising variation from conventional pragmatic RCTs. In this paper, we evaluate methodological challenges of conducting an RCT within a cohort. We argue that equally valid results can be obtained from trials conducted within cohorts as from pragmatic RCTs. However, whether this design is more efficient compared with conducting a pragmatic RCT depends on the amount and nature of non-compliance in the intervention arm. [ABSTRACT FROM AUTHOR]
- Subjects :
- RANDOMIZED controlled trials
HEALTH programs
INSTRUMENTAL variables (Statistics)
RANDOMIZATION (Statistics)
INFORMED consent (Medical law)
CLINICAL trials
COMPARATIVE studies
EXPERIMENTAL design
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
PATIENT compliance
RESEARCH
EVALUATION research
Subjects
Details
- Language :
- English
- ISSN :
- 03005771
- Volume :
- 46
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- International Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 122708476
- Full Text :
- https://doi.org/10.1093/ije/dyw050