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Cross-cultural validation of Lupus Impact Tracker in five European clinical practice settings.
- Source :
- Rheumatology; May2017, Vol. 56 Issue 5, p818-828, 13p, 1 Black and White Photograph, 6 Charts
- Publication Year :
- 2017
-
Abstract
- Objectives. The aim was to evaluate the cross-cultural validity of the Lupus Impact Tracker (LIT) in five European countries and to assess its acceptability and feasibility from the patient and physician perspectives. Methods. A prospective, observational, cross-sectional and multicentre validation study was conducted in clinical settings. Before the visit, patients completed LIT, Short Form 36 (SF-36) and care satisfaction questionnaires. During the visit, physicians assessed disease activity [Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA)-SLEDAI], organ damage [SLICC/ACR damage index (SDI)] and flare occurrence. Cross-cultural validity was assessed using the Differential Item Functioning method. Results. Five hundred and sixty-nine SLE patients were included by 25 specialists; 91.7% were outpatients and 89.9% female, with mean age 43.5(13.0) years. Disease profile was as follows: 18.3% experienced flares; mean SELENA-SLEDAI score 3.4 (4.5); mean SDI score 0.8 (1.4); and SF-36 mean physical and mental component summary scores: physical component summary 42.8(10.8) and mental component summary 43.0(12.3). Mean LIT score was 34.2(22.3) (median: 32.5), indicating that lupus moderately impacted patients' daily life. A cultural Differential Item Functioning of negligible magnitude was detected across countries (pseudo-R2 difference of 0.01-0.04). Differences were observed between LIT scores and Physician Global Assessment, SELENA-SLEDAI, SDI scores = 0 (P < 0.035) and absence of flares (P = 0.004). The LIT showed a strong association with SF-36 physical and social role functioning, vitality, bodily pain and mental health (P < 0.001). The LIT was well accepted by patients and physicians. It was reliable, with Cronbach a coefficients ranging from 0.89 to 0.92 among countries. Conclusion. The LIT is validated in the five participating European countries. The results show its reliability and cultural invariability across countries. They suggest that LIT can be used in routine clinical practice to evaluate and follow patient-reported outcomes in order to improve patient-physician interaction. [ABSTRACT FROM AUTHOR]
- Subjects :
- QUALITY of life
STATISTICAL correlation
HEALTH surveys
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
SCIENTIFIC observation
PROBABILITY theory
QUESTIONNAIRES
RESEARCH
RESEARCH evaluation
SELF-evaluation
SYSTEMIC lupus erythematosus
ACTIVITIES of daily living
CROSS-sectional method
SEVERITY of illness index
RESEARCH methodology evaluation
PATIENTS' attitudes
PHYSICIANS' attitudes
FUNCTIONAL assessment
DESCRIPTIVE statistics
DIFFERENTIAL item functioning (Research bias)
Subjects
Details
- Language :
- English
- ISSN :
- 14620324
- Volume :
- 56
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 122651181
- Full Text :
- https://doi.org/10.1093/rheumatology/kew492