Quantitative Ultrasound Measurement at the Hand Phalanges Does Not Reveal Skeletal Disturbances in Children With Bronchial Asthma: A Longitudinal Observation.

Objectives: To assess the skeletal status in asthmatic children treated with inhaled corticosteroids in a longitudinal observation by quantitative ultrasound (US) measurement at the hand phalanges. Methods: Thirty ‐ four children were studied prospectively. Quantitative US measurements were performed at baseline and after a mean ± SD of 2.35 ± 0.20 years. The obtained results were compared to age ‐ , sex ‐ , and body size ‐ matched control participants selected from a database of previously examined healthy children. Individual changes in the amplitude ‐ dependent speed of sound (Ad ‐ SoS) during the follow ‐ up period were also analyzed. Results: The mean age of the asthmatic children was 10.6 ± 2.5 years. The mean Ad ‐ SoS in the asthmatic children at baseline was 1940.5 ± 49.6 m/s, and the mean Z score was −0.26 ± 0.80. Corresponding values at the follow ‐ up examination were 1976.2 ± 63.6 m/s and −0.18 ± 1.16. The results did not differ significantly in comparison to the healthy controls. The analysis of individual changes in Ad ‐ SoS revealed that 18 participants had a significant increase in this parameter (ie, exceeding the least significant change threshold), and 16 did not have a significant change in their values. No one had a significant decrease in Ad ‐ SoS. Conclusions: Quantitative US at the hand phalanges applied as a diagnostic tool revealed no essential differences in the pattern of skeletal development between asthmatic children treated with inhaled glucocorticosteroids and healthy controls. [ABSTRACT FROM AUTHOR]