RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury.

The article discusses the use of RIG-I/MAVS and STING signaling, citing the molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) in tissue injury. It cites on the development graft-versus-host disease (GVHD) in mice used in laboratory research of allogeneic hematopoietic stem cell transplantation. The article also suggests that activation of either RIG-I/MAVS or STING pathways during the acute intestinal tissue injury.