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THE IMPACT OF CIRCADIAN RHYTHMS ON MEDICAL IMAGING AND RADIOTHERAPY REGIMES FOR THE PAEDIATRIC PATIENT.

Authors :
Forssell-Aronsson, E.
Quinlan, R. A.
Source :
Radiation Protection Dosimetry; Apr2017, Vol. 173 Issue 1-3, p16-20, 5p
Publication Year :
2017

Abstract

Daily rhythmic changes are found in cellular events in cell cycle, DNA repair, apoptosis and angiogenesis in both normal and tumour tissue, as well as in enzymatic activity and drug metabolism. In this paper, we hypothesize that circadian rhythms need to be considered in radiation protection and optimization in personalized medicine, especially for paediatric care. The sensitivity of the eye lens to ionizing radiation makes the case for limiting damage to the lens epithelium by planning medical radio-imaging procedures for the afternoon, rather than the morning. Equally, the tumour and normal tissue response to radiotherapy is also subject to diurnal variation enabling optimization of time of treatment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01448420
Volume :
173
Issue :
1-3
Database :
Complementary Index
Journal :
Radiation Protection Dosimetry
Publication Type :
Academic Journal
Accession number :
122342871
Full Text :
https://doi.org/10.1093/rpd/ncw328