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Phakellistatins: An Underwater Unsolved Puzzle.
- Source :
- Marine Drugs; Mar2017, Vol. 15 Issue 3, p78, 16p
- Publication Year :
- 2017
-
Abstract
- A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1-19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16603397
- Volume :
- 15
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Marine Drugs
- Publication Type :
- Academic Journal
- Accession number :
- 122252755
- Full Text :
- https://doi.org/10.3390/md15030078