A replication-defective human cytomegalovirus vaccine for prevention of congenital infection.

The article discusses a study on the use of a replication-defective human cytomegalovirus vaccine to prevent congenital infection. The study examined a vaccine candidate with genetic modifications to improve its immunogenicity and attenuation. It used a synthetic compound named Shield-1 to regulate viral replication. The results revealed that the vaccine induced neutralizing antibodies to multiple viral antigens.