Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection.

The article presents a study that analyzed the quality of HIV-specific CD8+ T cell responses emerging in the earliest stages of acute infection and assessed whether these responses could control viral replication and HIV reservoir seeding after antiretroviral therapy initiation. Topics discussed include HIV-specific CD8+ T cell expansion in the early stages of acute HIV-1 infection and loss of cytokine secretion and survival potential ofHIV-specific CD8+T cells during acute HIV infection.