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Moderately elevated maternal homocysteine at preconception is inversely associated with cognitive performance in children 4 months and 6 years after birth.
- Source :
- Maternal & Child Nutrition; Apr2017, Vol. 13 Issue 2, pn/a-N.PAG, 13p
- Publication Year :
- 2017
-
Abstract
- Prenatal methyl donor deficiency leads to homocysteine accumulation in the brain and impaired neurodevelopment in rats. We investigated the effect of moderately elevated preconception fasting total plasma homocysteine (tHcy) on child neurodevelopment in a prospective study of 67 and 76 mother-child pairs at 4 months and 6 years of age, respectively. Fasting blood samples at 2-10 weeks preconception, from the cord (nonfasting) and the mother and child 6 years after birth, were collected. Psychomotor and mental development were assessed at 4 months using the Bayley Scale of Infant Development (BSID) and cognitive development at 6 years using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). Highest tertile preconception tHcy (≥9.04 µmol/L) was categorized as moderately elevated and low-mid tertile tHcy as normal. Children, born to mothers with moderately elevated compared to normal preconception tHcy, scored lower [mean (95% CI)] in the BSID psychomotor [115 (105, 124) vs. 126 (121, 130), p = 0.03] and mental [101 (93, 109) vs. 113 (107, 119), p = 0.03] development tests. Multiple logistic regression analysis showed that moderately elevated compared to normal preconception tHcy was associated with greater probability, OR (95%CI), of scoring in the lowest tertile for BSID psychomotor development (≤120): 4.0 (1.1, 14.3) and lowest tertiles for WPPSI full (≤111), verbal (≤104) and performance (≤111), intellectual quotient: 6.0 (1.5, 23.7), 3.5 (1.1, 11.2) and 4.1 (1.1, 15.7), respectively. We conclude that moderately elevated preconception tHcy is inversely associated with psychomotor and cognitive development scores in infants and children. [ABSTRACT FROM AUTHOR]
- Subjects :
- ACADEMIC medical centers
CHI-squared test
CHILD Behavior Checklist
CHILD development
COGNITIVE testing
CONFIDENCE intervals
INFANT development
LONGITUDINAL method
MOTHERS
PSYCHOLOGY of movement
PROBABILITY theory
STATISTICS
T-test (Statistics)
HOMOCYSTEINE
DATA analysis
MULTIPLE regression analysis
DATA analysis software
STATE-Trait Anxiety Inventory
DESCRIPTIVE statistics
PRENATAL exposure delayed effects
ODDS ratio
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 17408695
- Volume :
- 13
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Maternal & Child Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 122198109
- Full Text :
- https://doi.org/10.1111/mcn.12289