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Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone.

Authors :
Price, Trevor T.
Burness, Monika L.
Sivan, Ayelet
Warner, Matthew J.
Renee Cheng
Lee, Clara H.
Olivere, Lindsey
Comatas, Karrie
Magnani, John
Lyerly, H. Kim
Qing Cheng
McCall, Chad M.
Sipkins, Dorothy A.
Source :
Science Translational Medicine; 5/25/2016, Vol. 8 Issue 340, p1-11, 11p, 4 Graphs
Publication Year :
2016

Abstract

The article discusses the dormant behavior of breast cancer which occur following a therapy through bones. It states that the patients diagnosed with breast cancer are treated with adjuvant therapy despite of the risk for late metastatic relapse. It also cites the detection of cancer stem cells (CSCs) in the peripheral blood of cancer patients.

Details

Language :
English
ISSN :
19466234
Volume :
8
Issue :
340
Database :
Complementary Index
Journal :
Science Translational Medicine
Publication Type :
Academic Journal
Accession number :
122147657
Full Text :
https://doi.org/10.1126/scitranslmed.aad4059