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Global DNA hypomethylation has no impact on lung function or serum inflammatory and fibrosis cytokines in asbestos-exposed population.
- Source :
- International Archives of Occupational & Environmental Health; Apr2017, Vol. 90 Issue 3, p265-274, 10p
- Publication Year :
- 2017
-
Abstract
- Purpose: To examine the effect of asbestos exposure on global DNA methylation and determine whether lung function and inflammatory and fibrosis biomarkers are correlated with the methylation state. Methods: A total of 26 healthy subjects without asbestos exposure (Group 1), 47 healthy subjects with exposure (Group 2), and 52 subjects with benign asbestos-related disorders (ARDs) (Group 3) participated in this cross-sectional study. Blood global 5-methylcytosine (5mC) and serum TNF-α, collagen IV, CCL5 and CC16 concentrations were analyzed using enzyme-linked immunosorbent assay-like assays. Spirometric maneuvers were performed to assess lung function. Results: Decreased 5mC levels were observed in Groups 2 and 3 compared to Group 1, irrespective of lung function ( p < 0.01). There was no significant change in 5mC between Groups 2 and 3. Overall, 5mC was negatively correlated with CCL5 and collagen IV ( p < 0.05), but no significant inverse relationship was found between 5mC and CCL5 or collagen IV in each group. Additionally, both 5mC and CC16 were inversely associated with FEV1/FVC% ( p = 0.001, adjusted R = 0.145) for non-smokers, and consistently significant inverse relationships were found between CC16 and FEV1/FVC%, independent of asbestos exposure. Conclusions: Asbestos exposure causes global DNA hypomethylation. DNA hypomethylation has no influence on serum biomarkers and lung function in asbestos-exposed population with or without pleural and pulmonary parenchymal abnormalities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03400131
- Volume :
- 90
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- International Archives of Occupational & Environmental Health
- Publication Type :
- Academic Journal
- Accession number :
- 121976517
- Full Text :
- https://doi.org/10.1007/s00420-017-1195-1