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How tRNAs dictate nuclear codon reassignments: Only a few can capture non-cognate codons.
How tRNAs dictate nuclear codon reassignments: Only a few can capture non-cognate codons.
- Source :
- RNA Biology; 2017, Vol. 14 Issue 3, p293-299, 7p
- Publication Year :
- 2017
-
Abstract
- mRNA decoding by tRNAs and tRNA charging by aminoacyl-tRNA synthetases are biochemically separated processes that nevertheless in general involve the same nucleotides. The combination of charging and decoding determines the genetic code. Codon reassignment happens when a differently charged tRNA replaces a former cognate tRNA. The recent discovery of the polyphyly of the yeast CUG sense codon reassignment challenged previous mechanistic considerations and led to the proposal of the so-calledtRNA loss driven codon reassignmenthypothesis. Accordingly, codon capture is caused by loss of a tRNA or by mutations in the translation termination factor, subsequent reduction of the codon frequency through reduced translation fidelity and final appearance of a new cognate tRNA. Critical for codon capture are sequence and structure of the new tRNA, which must be compatible with recognition regions of aminoacyl-tRNA synthetases. The proposed hypothesis applies to all reported nuclear and organellar codon reassignments. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 15476286
- Volume :
- 14
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- RNA Biology
- Publication Type :
- Academic Journal
- Accession number :
- 121925564
- Full Text :
- https://doi.org/10.1080/15476286.2017.1279785