Prothymosin α, a mammalian c-myc-regulated acidic nuclear protein, provokes the decondensation of human chromosomes in vitro.

Prothymosin (ProTα) is an acidic nuclear protein, widely distributed in mammalian cells, whose expression is regulated by c-myc and linked to cell proliferation. ProTα interacts with histone H1 via its acidic domain, and its overexpression provokes the unfolding of chromatin fibers. Here we show that incubation of human native metaphase chromosomes with ProTα induces their extensive unravelling suggesting a function of this protein in chromosome decondensation. Copyright © 2001 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]