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Water-Soluble Polymer Nanoparticles Constructed by Three-Component Self-Assembly: An Efficient Theranostic Agent for Phosphorescent Imaging and Photodynamic Therapy.
- Source :
- Chemistry - A European Journal; 3/13/2017, Vol. 23 Issue 15, p3728-3734, 7p
- Publication Year :
- 2017
-
Abstract
- Water-soluble polymer nanoparticles NP-1 and NP-2 were prepared by using a three-component self-assembly of an iridium complex, poly(4-vinyl pyridine-b-ethylene oxide) (P4VP-b-PEO), and methane sulfonic acid (MSA). Due to the unique metal-ligand charge-transfer transition property and the heavy-atom effect of the iridium atom, NP-1 and NP-2 showed bright phosphorescence and generated the singlet oxygen (<superscript>1</superscript>O<subscript>2</subscript>) species effectively under visible-light irradiation ( λ>400 nm) with a power density of 300 mW cm<superscript>−2</superscript>. NP-2, an example of the polymer nanoparticles, showed minimal cytotoxic activity in the dark. Laser confocal fluorescence and flow-cytometry microscopy experiments demonstrated that NP-2 could be taken up by a model cancer-cell line of 4T1 cells, which could be used as a phosphorescent probe for cell imaging by preferentially staining the cytoplasm. After 6 hours of incubation with NP-2 (100 μg mL<superscript>−1</superscript>), the cell viability of 4T1 cells decreased to approximately 10 % upon visible-light irradiation ( λ>400 nm, 300 mW cm<superscript>−2</superscript>) only for 10 minutes as a result of the generation of the <superscript>1</superscript>O<subscript>2</subscript> species, thus indicating a proof of concept for effective photodynamic therapy for cancer cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 23
- Issue :
- 15
- Database :
- Complementary Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 121807916
- Full Text :
- https://doi.org/10.1002/chem.201605150