Back to Search
Start Over
Effectiveness of deep versus moderate muscle relaxation during laparoscopic donor nephrectomy in enhancing postoperative recovery: study protocol for a randomized controlled study.
- Source :
- Trials; 3/4/2017, Vol. 18, p1-7, 7p, 1 Diagram, 2 Charts
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Postoperative recovery after live donor nephrectomy is largely determined by the consequences of postoperative pain and analgesia consumptions. The use of deep neuromuscular blockade has been shown to reduce postoperative pain scores after laparoscopic surgery. In this study, we will investigate whether deep neuromuscular blockade also improves the early quality of recovery after live donor nephrectomy.<bold>Methods: </bold>The RELAX-study is a phase IV, multicenter, double-blinded, randomized controlled trial, in which 96 patients, scheduled for living donor nephrectomy, will be randomized into two groups: one with deep and one with moderate neuromuscular blockade. Deep neuromuscular blockade is defined as a post-tetanic count of 1-2. Our primary outcome measurement will be the Quality of Recovery-40 questionnaire (overall score) at 24 h after extubation.<bold>Discussion: </bold>This study is, to our knowledge, the first randomized study to assess the effectiveness of deep neuromuscular blockade during laparoscopic donor nephrectomy in enhancing postoperative recovery. The study findings may also be applicable for other laparoscopic procedures.<bold>Trial Registration: </bold>clinicaltrials.gov, NCT02838134 . Registered on 29 June 2016. [ABSTRACT FROM AUTHOR]
- Subjects :
- POSTOPERATIVE care
RECOVERY rooms
ANALGESIA
NEUROMUSCULAR blocking agents
MUSCLE relaxants
NEPHRECTOMY
POSTOPERATIVE pain prevention
COMPARATIVE studies
CONVALESCENCE
EXPERIMENTAL design
KIDNEY transplantation
LAPAROSCOPY
RESEARCH methodology
MEDICAL care research
MEDICAL cooperation
RESEARCH protocols
MUSCLE contraction
ORGAN donors
POSTOPERATIVE pain
QUALITY of life
QUESTIONNAIRES
RESEARCH
TIME
EVALUATION research
PAIN measurement
RANDOMIZED controlled trials
TREATMENT effectiveness
BLIND experiment
Subjects
Details
- Language :
- English
- ISSN :
- 17456215
- Volume :
- 18
- Database :
- Complementary Index
- Journal :
- Trials
- Publication Type :
- Academic Journal
- Accession number :
- 121614336
- Full Text :
- https://doi.org/10.1186/s13063-017-1785-y