Four new C 10 -polyacetylene glycosides from the rhizomes of Atractylodes lancea.

An ongoing phytochemical investigation of the rhizomes ofAtractylodes lancearesulted in the isolation of four new C10-type polyacetylene glycosides (1−4). Their structures were elucidated on the basis of extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HRESIMS). The absolute configurations of compounds2−4were determined by comparing the specific rotations of their aglycones. Notably, compounds2and3exhibited significant hepatoprotective activities against APAP-induced HepG2 cell injury at a concentration of 10 μM. Compounds2and3showed weak anti-inflammatory effects on LPS-induced NO production in microglia BV2 cells at a concentration of 10 μM. [ABSTRACT FROM PUBLISHER]