Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi.

Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, againstCandida albicansbiofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi. [ABSTRACT FROM PUBLISHER]