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Expression of erythropoietin and neuroendocrine markers in clear cell renal cell carcinoma.
- Source :
- APMIS; Mar2017, Vol. 125 Issue 3, p213-222, 10p
- Publication Year :
- 2017
-
Abstract
- The aim of the study was to investigate the expression of erythropoietin and neuroendocrine markers in clear cell renal cell carcinoma ( CCRCC). We retrospectively reviewed the medical records and re-evaluated histopathological specimens of 33 patients with CCRCC and compared with those of 11 cases of non- CCRCC. All patients were treated with a partial or radical nephrectomy at St. Olavs Hospital, Trondheim University Hospital, between 2010 and 2016. Thirty-three patients who were diagnosed with CCRCC had a total of 35 tumours, where 34 of the tumours were CCRCC and one was papillary adenoma. Thirty-three (97%) of 34 CCRCCs were positive for erythropoietin, and the same 33 (97%) tumours demonstrated strong expression for neuron-specific enolase ( NSE). Two (6%) of 34 CCRCCs had a positive reaction for synaptophysin, and three (9%) of 34 were positive for CD56. Erythropoietin and NSE were negative in non- CCRCCs, and chromogranin A was negative in all tumours. The above findings suggest that there is a strong association between CCRCC and the expression of erythropoietin and NSE. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09034641
- Volume :
- 125
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- APMIS
- Publication Type :
- Academic Journal
- Accession number :
- 121408022
- Full Text :
- https://doi.org/10.1111/apm.12654