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Predictive factors and treatment outcome of laryngeal carcinoma recurrence.
- Source :
- Head & Neck; Mar2017, Vol. 39 Issue 3, p555-563, 9p
- Publication Year :
- 2017
-
Abstract
- Background Up to 30% of patients with laryngeal squamous cell carcinoma (SCC) present with recurrence after treatment. We analyzed factors associated with the risk of cancer recurrence and prognosis after recurrence. Methods A nationwide laryngeal SCC cohort from Finnish university hospitals during 2001 to 2005 with initial successful therapy ( n = 316) was analyzed. Results Laryngeal SCC recurred in 22% of patients. The median time to recurrence was 9 months, with 90% occurring within 36 months after treatment. The World Health Organization (WHO) performance status >0, neck metastasis at presentation, and nonsurgical treatment were independent prognostic factors for recurrence. Patients with local recurrence had a 5-year overall survival (OS) of 53% compared with 5% in patients with regional/distant recurrences. OS for glottic and nonglottic laryngeal SCC recurrence was 45% and 0%, respectively. Conclusion The type of treatment affected the risk of recurrence in this retrospective series. Local recurrences carried a chance for successful salvage treatment. Routine follow-up beyond 36 months remains controversial. © 2016 Wiley Periodicals, Inc. Head Neck 39: 555-563, 2017 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10433074
- Volume :
- 39
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Head & Neck
- Publication Type :
- Academic Journal
- Accession number :
- 121348270
- Full Text :
- https://doi.org/10.1002/hed.24642