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The ORACLE Children Study: educational outcomes at 11 years of age following antenatal prescription of erythromycin or co-amoxiclav.
- Source :
- Archives of Disease in Childhood -- Fetal & Neonatal Edition; Mar2017, Vol. 102 Issue 2, pF131-F135, 5p, 4 Charts
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Antibiotics used for women in spontaneous preterm labour without overt infection, in contrast to those with preterm rupture of membranes, are associated with altered functional outcomes in their children.<bold>Methods: </bold>From the National Pupil Database, we used Key Stage 2 scores, national test scores in school year 6 at 11 years of age, to explore the hypothesis that erythromycin and co-amoxiclav were associated with poorer educational outcomes within the ORACLE Children Study.<bold>Results: </bold>Anonymised scores for 97% of surviving children born to mothers recruited to ORACLE and resident in England were analysed against treatment group adjusting for key available socio-demographic potential confounders. No association with crude or with adjusted scores for English, mathematics or science was observed by maternal antibiotic group in either women with preterm rupture of membranes or spontaneous preterm labour with intact membranes. While the proportion receiving special educational needs was similar in each group (range 31.6-34.4%), it was higher than the national rate of 19%.<bold>Conclusions: </bold>Despite evidence that antibiotics are associated with increased functional impairment at 7 years, educational test scores and special needs at 11 years of age show no differences between trial groups.<bold>Trial Registration Number: </bold>ISCRT Number 52995660 (original ORACLE trial number). [ABSTRACT FROM AUTHOR]
- Subjects :
- EDUCATIONAL outcomes
ERYTHROMYCIN
DRUG prescribing
PRENATAL care
BIOLOGICAL membranes
ANTIBIOTICS
CHILD development
COMMUNICABLE diseases
DATABASES
EDUCATIONAL tests & measurements
ENZYME inhibitors
HEALTH outcome assessment
PREGNANCY complications
QUESTIONNAIRES
RESEARCH funding
PRENATAL exposure delayed effects
Subjects
Details
- Language :
- English
- ISSN :
- 13592998
- Volume :
- 102
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Archives of Disease in Childhood -- Fetal & Neonatal Edition
- Publication Type :
- Academic Journal
- Accession number :
- 121336548
- Full Text :
- https://doi.org/10.1136/archdischild-2015-310144