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Oroxylin A inhibits H 2 O 2 -induced oxidative stress in PC12 cells.
- Source :
- Natural Product Research; Jun2017, Vol. 31 Issue 11, p1339-1342, 4p
- Publication Year :
- 2017
-
Abstract
- Oroxylin A, a natural flavonoid isolated from Scutellaria baicalensis, has been reported to have anti-inflammatory and antioxidant effects. However, suppression of oxidative stress and neuroapoptosis by oroxylin A is largely uninvestigated. To investigate the protective effects of oroxylin A, PC12 cells were exposed to oroxylin A and hydrogen peroxide solutions and measured. Oroxylin A significantly reduced the levels of intracellular calcium and reactive oxygen species and increased the levels of CAT and Mn/SOD. Oroxylin A also inhibited the activation of caspase-3. These results suggest that treatment of PC12 cells with oroxylin A inhibits H<subscript>2</subscript>O<subscript>2</subscript>-induced oxidative stress. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 31
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 121333404
- Full Text :
- https://doi.org/10.1080/14786419.2016.1244193