Urease inhibition potential of Di-naphthodiospyrol from Diospyros lotus roots.

The dimeric napthoquione 5,8,4′-trihydroxy-1′-methoxy-6, 6′-dimethyl-7,3′-binaphtyl-1,4,5′,8′-tetraone (1) was isolated from the chloroform fraction ofDiospyros lotusextract.Compound1was screened for its inhibitory effects against four enzymes: urease, phosphodiesterase-I, carbonic anhydrase-II andα-chymotrypsin, and showed selective activity against urease enzyme with an IC50value of 254.1 ± 3.82 μM as compared to the standard thiourea (IC50 = 21 ± 0.11 μM). Furthermore,in silicodocking study was carried out to explain the molecular mechanism of compound1against the target receptor. [ABSTRACT FROM PUBLISHER]